Charlie Mascarenhas (Abhishek Bachchan) and his accomplice Riya Thappar (Bipasha Basu) are one of the most popular thief-duos in India. A friend of Charlie, Raj (Aftab Shivdasani) is killed by the Russian mafia. At Raj's funeral his wife hands over a CD to Charlie, which contains details of how Russian gold will be transferred to Romania. Charlie decides to rob the train with the help of imprisoned con-artist Victor Braganza (Vinod Khanna). They hire a team of people to join them in the robbery. The group includes Spider (Neil Nitin Mukesh) who is a hacker, an explosives expert named Bilal Basheer (Sikander Kher), a master-disguiser called Sunny Mehra (Omi Vaidya), and an illusionist in the name of Ronnie (Bobby Deol).

Charlie is also having an affair with Victor's daughter, Naina (Sonam Kapoor), who doesn't know anything about her father and Charlie's business. The group hatch a plan to rob the Russian train. Spider hacks the Russian satellite system while Ronnie uses his illusion to trick the soldiers guarding the gold and the rest of the Players transfer the gold off the train. The robbery is executed successfully. However, whilst celebrating their success, it is revealed that Spider has double crossed the players, and tries to flee with the whole gold, though is stopped by Ronnie, who is then shot multiple times by Spider's assassins. The group are then chased by them, only leading to Ronnie and Riya's death. Charlie, Bilal and Sunny manage to escape when Spider bombs the place and flees with the gold.

Charlie calls Victor to tell him about the betrayal, but Naina hears everything. A team of Spider's assassins break into the house to murder Victor, but Dada, though quite old, fights them off. As he and Naina are about to flee, Victor is shot in the back multiple times by a sniper and dies in Naina's arms. Naina decides to end her contact with Charlie. For over a year, Charlie contacts Gold-dealers to find which one has the same gold Spider stole. In New Zealand, they find a dealer who is in contact with him, and are able to track him down. Charlie explains to Naina that they only wanted to steal the gold so they could help achieve Victor's dream to make an big orphanage. Naina understands, and teams up with Charlie to get revenge on Spider.

In New Zealand they find Riya, who is still alive and living there. She explains that she also wants revenge on Spider and provides them with information of Spider's location. Spider then flirts with Naina (unknowing her plan) and takes her to his villa. But soon enough, he gets her on gunpoint, finding out she was with Charlie as he sees a camera inside her hair. Charlie runs in to rescue her and challenges Spider that he will steal all the gold within 48 hours. Spider tries to move the gold to another country, but the Players, using three large trucks and by hacking the traffic system successfully manage to take the gold before hiding it inside three Mini Coopers. Just as they are about to leave the country, they are caught by Spider, and it turns out that Riya was working with Spider the whole time.